Dog with mosquito on nose
ProHeart 12 (moxidectin)

ONE BITE* can give a dog heartworm disease. ONE ProHeart 12 injection ensures ONE FULL YEAR of constant protection.

ProHeart 12 is the only once-yearly injection to prevent heartworm disease in dogs

A convenient once-a-year injection—so you don’t have to worry about forgetting a monthly dose and leaving your best friend exposed to heartworm disease.

*From an infected mosquito. Caused by Dirofilaria immitis.

See why it only takes ONE with ProHeart 12

Woman holding dog

ProHeart 12 is here year-round to protect your dog

ProHeart 12 fits in with annual wellness visits

With no monthly doses to remember, there are no gaps in protection for a full year. It’s so important to keep your dog protected. Just one missed dose of any heartworm preventative can result in heartworm disease, a potentially fatal condition.

Just one shot of ProHeart 12 provides protection for your dog all year long.

Learn More

Ask your veterinarian about the benefits of ProHeart 12

woman hugging dog

It only takes one

ProHeart 12 makes it simple to protect your dog from heartworm disease.

Three dogs with mosquito

Heartworm disease is preventable—but are monthly chewables right for you and your dog?

There are other options to prevent heartworm disease, but before you commit to monthly chewables, consider this:

  • When life gets busy, it can be tough to stay on top of monthly dosing—and many pet owners do forget1
  • Dogs may vomit or spit out the chews, which means the pet owner has to redose
  • Some dogs refuse to eat “treat-like” preventatives

Monthly chewables offer 12 chances to miss a dose!

See what pet owners and veterinarians are saying about ProHeart 12

View Testimonials

One dose: constant protection for your dog means constant peace of mind for you

Heartworm disease can be deadly. ProHeart 12 is a long-lasting injectable that prevents heartworm disease for 12 months, plus:

  • You can easily fit in heartworm disease prevention with ProHeart 12 when you go for your dog’s yearly vet visit
  • The convenience of a once-a-year injection means you don’t have to worry about forgetting a monthly dose and putting your dog at risk for heartworm disease
Veterinarian with white dog

ProHeart 12 is effective & safe

In a real-world study, ProHeart 12:

  • Was 100% effective against heartworm* in dogs
  • Was found to be safe for most types of dogs, including:
    • Reproducing dogs and their puppies
    • Collies sensitive to ivermectin—a common ingredient in monthly heartworm products
  • Had a similar adverse event profile to Heartgard® Plus

*Caused by Dirofilaria immitis. In 3 well-controlled studies.
Heartgard Plus is a registered trademark of Boehringer Ingelheim.

What Pet Owners and Doctors are saying about ProHeart 12

Man sitting with dog on couch

Year-round protection has a lot of benefits. Hear what pet owners have to say about what ProHeart does for their dogs, their families and their peace of mind.

Mosquito flying

How do dogs get infected with heartworms?

The short answer: mosquitoes. A single bite from an infected mosquito can put your dog at risk for developing heartworm disease.

  1. An infected mosquito bites your dog, infecting your dog with heartworm larvae.
  2. The heartworms then mature inside your dog, living in major vessels around the heart and even sometimes inside the heart itself.
  3. It could take longer than 7 months for the heartworms to be detectable with routine testing. An adult heartworm can grow up to a foot in length, living inside your dog’s heart and lungs.4

Any dog, even your dog, could become infected

Heartworm disease has been diagnosed in every state and is a serious threat to your dog.

  • Early disease and damage can happen even before a test can detect heartworms5
  • Heartworm disease has increased over 21% during a 3-year period and is expected to continue to spread*6,7
  • Treating heartworm is up to 25 times more expensive than simply preventing it8
    • Once a dog is diagnosed with heartworm disease, a pet owner may have to pay for doctor’s visits, medications, post-treatment preventatives, lab tests, x-rays, and other medical expenses

*Per veterinary clinic, 2013-2016. Calculation is based on American Heartworm Society cost estimations of treatment vs prevention (where heartworm prevention range is $70-$200, and heartworm treatment range is $1,200-$1,800; [low range] $1,200/$70=17.14, [high range] $1,800/$200=9, [High/Low comparison] $1,800/$70=25.71).

Dog laying on grass

ProHeart 6® (moxidectin): another reliable option

ProHeart 6 is a twice-yearly injection to prevent heartworm disease in dogs

  • 20 million doses sold over a 10‑year period9
  • Safe in special populations like:
    • Reproducing dogs and their puppies
    • Dogs sensitive to ivermectin—a common ingredient in monthly heartworm products
  • Many common medicines were given at the same time in clinical trials

Please see full Prescribing Information for ProHeart 6.

Zoetis Petcare Rewards program for ProHeart purchases

Earn rewards while protecting your dog from heartworm disease

Frequently asked questions

Find answers to common questions about ProHeart products

Important Safety Information: Use PROHEART 6 in dogs 6 months of age or older and PROHEART 12 in dogs 12 months of age or older. Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. Hypersensitivity reactions may occur in some dogs when PROHEART is administered alone or with vaccines. Anaphylactic and anaphylactoid reactions can result in death and should be treated immediately with the same measures used to treat hypersensitivity reactions to vaccines and other injectable products. Reported side effects in clinical trials included vomiting, lethargy, diarrhea, anorexia, and hypersensitivity reactions. People should avoid inhalation, contact with eyes, or accidental self-injection. Certification is required before veterinarians and staff administer these products. See full Prescribing Information for ProHeart 6 and ProHeart 12.

  1. Make Heartworm Preventative Reminders a Priority.
  2. ProHeart 12 Pharmacovigilance Data. Data on file. Zoetis Inc.
  3. Volume 6C: Summary of the Product Characteristics: SPC - Pharmaceuticals 2006. Data on file. Zoetis Inc.
  4. AHS Canine Guidelines 2018.
  5. Jones S. Heartworm disease: What lies beneath; DVM 360. April 19, 2018.
  6. Drake J, Wiseman S. Increasing incidence of Dirofilaria immitis in dogs in USA with focus on the southeast region 2013-2016. Parasit Vectors. (2018)11:39.
  7. AHS announces findings of New Heartworm Incidence Survey. April 17, 2017.
  8. Weigh the costs: Heartworm treatment vs Heartworm prevention.
  9. ProHeart 6 Pharmacovigilance Data. Data on file. Zoetis Inc.

©2019 Zoetis Services LLC. All rights reserved. PHT‑00017