The First FDA-Approved Product of Its Kind

Simparica Trio is a once-a-month chewable that protects your dog with three proven ingredients designed for defense. It's available from your vet with a prescription and comes with a 100% satisfaction guarantee.

  • Protects dogs against heartworm disease, ticks & fleas, roundworms & hookworms.
  • FDA-approved to block infections that may cause Lyme disease by killing deer ticks.
  • Demonstrated safe for puppies as young as 8 weeks old, weighing at least 2.8 lbs.

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It’s Time to Enhance Your Dog’s Protection

Enhance Your Dog's Protection
  • Studies to support FDA approval showed that 1 dose of Simparica Trio provided 100% protection against heartworm disease.
  • Proven to kill 5 types of ticks.
  • Prevents flea infestation by killing fleas before they can even lay eggs. Starts killing within 4 hours, and achieved 100% effectiveness in 8 hours in a study.
  • Treats and controls roundworms and hookworms to protect your dog from intestinal parasites.

Why Your Dog Needs Protection

See why it’s so important to protect your best friend.

Resources For You

Frequently Asked Questions

Important Safety Information: See Prescribing Information. Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.


  1. AHS Canine Guidelines 2018.
  2. Centers for Disease Control and Prevention. Geographic distribution of ticks that bite humans. Updated June 1, 2015. Accessed March 19, 2019.
  3. Companion Animal Parasite Council. Ticks. April 12, 2017. Accessed September 10, 2019.
  4. Byron L. Blagburn, BS, MS, PhD.*, Michael W. Dryden, DVM, PhD. Biology, Treatment, and Control of Flea and Tick Infestations. 2009; 4.
  5. Flea Allergy Dermatitis in Cats and Dogs. VetStreet website. Updated Apr 22, 2014. Accessed Mar 21, 2019.
  6. Lyme Disease. CDC. Accessed March 14, 2019.
  7. How ticks spread disease. Centers for Disease Control and Prevention website. Updated January 10, 2019. Accessed March 19, 2019.
  8. Little SE. Changing paradigms in understanding transmission of canine tick-borne diseases: the role of interrupted feeding and intrastadial transmission. In: Proceedings of the 2nd Canine Vector-Borne Disease (CVBD) Symposium; April 25-28, 2007; Sicily, Italy.
  9. Fleas, ticks & your pet. Companion Animal Parasite Council (CAPC) website. Updated March 2011. Accessed March 25, 2019.
  10. Eisen RJ, Eisen L, Ogden NH, Beard CB. Linkages of Weather and Climate With Ixodes scapularis and Ixodes pacificus (Acari: Ixodidae), Enzootic Transmission of Borrelia burgdorferi, and Lyme Disease in North America. J Med Entomol. 2016 Mar;53(2):250-61. doi: 10.1093/jme/tjv199. PMID: 26681789; PMCID: PMC4844560.