A woman hugging her dog
Protect him with all your heart
Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets)

All this protection in just one monthly chewable

Protect your dog with three proven ingredients designed for defense.

A heart icon, tick and flea icons, and roundworm & hookworm icons.

Earn up to $55 in rewards from Simparica Trio

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A woman outside with her dog, hugging it from behind, both are surrounded by the triple-color Simparica Trio ring to visually represent protection from disease.

Why Simparica Trio?

Simparica Trio makes it simple to deliver the protection every best friend deserves. Try it today and earn up to $55 in rewards on your Simparica Trio purchase.

  • Protects dogs against heartworm disease, ticks & fleas, roundworms & hookworms
  • Demonstrated safe for puppies as young as 8 weeks old, weighing at least 2.8 lbs
  • Tasty chewable that you only need to give once a month
  • FDA-approved and available with a vet’s prescription

See the Simparica Trio difference

Compare the labels of other products with Simparica Trio

Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets) Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets)
Prevents heartworm disease dark green checkmark
Kills 5 types of ticks dark green checkmark
Kills fleas dark green checkmark
Kills fleas before they can lay eggs dark green checkmark
Treats roundworms dark green checkmark
Treats hookworms dark green checkmark
Approved for puppies as young as 8 weeks dark green checkmark
Approved for dogs 2.8 lbs + dark green checkmark

Heartgard® and NexGard® are registered trademarks of Boehringer Ingelheim Animal Health USA Inc.8,9
Credelio®, Interceptor®, and Trifexis® are registered trademarks of Elanco or its affiliates.10,11,12
Bravecto® is a registered trademark of Intervet Inc. d/b/a Merck Animal Health.13

Satisfaction Guarantee

  • Heartworm disease
  • Ticks
  • Fleas
  • Roundworms & hookworms
  • Lyme disease*

We want you to be 100% satisfied with Simparica Trio. We’ll work with you to make sure you’re satisfied with Simparica Trio’s performance. If for any reason you’re still not completely happy, we’ll send you a replacement or give you your money back. Simply give us a call at 1‑888‑ZOETIS1 and we’ll take care of you.

Download complete Satisfaction Guarantee

*In a study, Simparica Trio was shown to kill ≥94.2% of existing deer tick infestations within 24 hours. Lyme disease is typically transmitted in 24‑48 hours.14

A man hugging his golden retriever close, surrounded by the triple-color Simparica Trio ring to visually present the protection Simparica Trio gives.

Heartworm disease can be fatal, and it only takes one bite from an infected mosquito†

  • Heartworm disease is a year-round threat
  • Heartworm disease has been diagnosed in all 50 states
  • Even with routine testing, it can take up to nine months to detect6
  • Heartworm disease can be deadly

Simparica Trio provides convenient heartworm disease protection for dogs

A silhouette of a dog with 1 monthly dose written inside, surrounded by the Simparica Trio rings to visually represent protection.

Try Simparica Trio, proven to protect your dog against heartworm disease, ticks & fleas, and roundworms & hookworms in just one monthly dose.

A male pet owner kneeling next to his dog, surrounded by the triple-color Simparica Trio ring to visually present the protection Simparica Trio gives.

Ticks and fleas: small pests, year round problems

Tick and flea infestations can happen to any dog, outdoor or indoor. Ticks are responsible for transmitting at least 15 different serious diseases to dogs, including Lyme disease.1 See how one simple chewable can protect against ticks and fleas.

Try Simparica Trio, proven to protect your dog against heartworm disease, ticks & fleas, and roundworms & hookworms in just one monthly dose.

A female pet owner kissing her dog outside, surrounded by the triple-color Simparica Trio ring to visually present the protection Simparica Trio gives.

Roundworms and hookworms can hurt your dog

  • Intestinal parasites can grow throughout the intestines
  • Symptoms include stomach swelling, vomiting, diarrhea and dehydration
  • Infected dogs can contaminate the home, putting other pets and people at risk
  • Puppies are more commonly infected

Try Simparica Trio, proven to protect your dog against heartworm disease, ticks & fleas, and roundworms & hookworms in just one monthly dose.

Purchase Simparica Trio, earn points. Image of outline of jar with paw print. Redeem your points for rewards. Image of outline radiating star. Spend rewards at the veterinarian. Image of dollar sign.

Earn up to $55 in rewards with your Simparica Trio purchase

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A dog peeking over a desk with an old-fashioned alarm clock to the side, the dog is surrounded by the triple-color Simparica Trio ring to visually present the protection Simparica Trio gives.

Remind me about Simparica Trio dosing

To keep your dog protected with Simparica Trio, it’s important to give your dog their tasty chewable at the same time every month.

Make dosing easy with our free monthly reminder emails and/or text messages.

Sign up for Monthly Reminders

A woman hugging a puppy outside, surrounded by the triple-color Simparica Trio ring to visually present the protection Simparica Trio gives.

Simparica Trio
Frequently Asked Questions

Important Safety Information: Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information.

References:
  1. Companion Animal Parasite Council. Ticks. April 12, 2017. https://capcvet.org/guidelines/ticks. Accessed September 10, 2019.
  2. Centers for Disease Control and Prevention. Geographic distribution of ticks that bite humans. http://www.cdc.gov/ticks/geographic_distribution.html. Updated June 1, 2015. Accessed March 19, 2019.
  3. How ticks spread disease. Centers for Disease Control and Prevention website. https://www.cdc.gov/ticks/life_cycle_and_hosts.html. Updated January 10, 2019. Accessed March 19, 2019.
  4. Little SE. Changing paradigms in understanding transmission of canine tick-borne diseases: the role of interrupted feeding and intrastadial transmission. In: Proceedings of the 2nd Canine Vector-Borne Disease (CVBD) Symposium; April 25-28, 2007; Sicily, Italy.
  5. Flea Allergy Dermatitis in Cats and Dogs. Vet Street website. http://www.vetstreet.com/care/flea-allergy-dermatitis-in-cats-and-dogs. Updated April 22, 2014. Accessed March 21, 2019.
  6. AHS Canine Guidelines 2018. https://d3ft8sckhnqim2.cloudfront.net/images/pdf/2018-AHS-Canine-Guidelines-181114.pdf?1542248135.
  7. Byron L. Blagburn, BS, MS, PhD.*, MichaelW. Dryden, DVM, PhD. Biology, Treatment, and Control of Flea and Tick Infestations. 2009; 4.
  8. NexGard® [package insert], Duluth, GA: Merial; 2015.
  9. Heartgard® [package insert], Duluth, GA: Merial; 2010.
  10. Credelio® [package insert], Greenfield, IN: Elanco; 2017.
  11. Interceptor® Plus [package insert]. Greenfield, IN: Elanco; 2019.
  12. Trifexis® [package insert], Greenfield, IN: Elanco; 2016.
  13. Bravecto® [package insert], Summit, NJ: Merck & Co; 2014.
  14. Honsberger NA, Six RH, Heinz TJ, et al. Efficacy of sarolaner in the prevention of Borrelia burgdorferi and Anaplasma phagocytophilum transmission from infected Ixodes scapularis to dogs. Vet Parasitol. 2016;222:67-72.

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The product information provided in this site is intended only for residents of the United States. The products discussed herein may not have marketing authorization or may have different product labeling in different countries. The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient.

All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted.
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