*By killing deer ticks. †For the treatment and control of Amblyomma americanum, Amblyomma maculatum, Dermacentor variabilis, Haemaphysalis longicornis, Ixodes scapularis, Rhipicephalus sanguineus. ‡Ixodes scapularis, Dermacentor variabilis, Amblyomma americanum, Rhipicephalus sanguineus, and Haemaphysalis longicornis. §Ixodes scapularis, Dermacentor variabilis, Amblyomma americanum, and Rhipicephalus sanguineus. #Ixodes scapularis, Dermacentor variabilis, Rhipicephalus sanguineus, and Haemaphysalis longicornis for 12 weeks. Bravecto is not effective against Amblyomma americanum beyond 8 weeks after dosing. **Amblyomma americanum, Dermacentor variabilis, Ixodes scapularis, Rhipicephalus sanguineus, Uncinaria stenocephala, Dipylidium caninum, Taenia pisiformis, and Echnicoccus granulosus. ††Simparica Trio starts killing deer ticks within 8 hours and starts killing fleas within 4 hours. ‡‡For the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina). §§For the treatment of hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections. ##For the prevention of Dipylidium caninum (tapeworm) infections, by killing fleas.
The Simparica Trio Difference
Tired of using multiple pest products? Simparica Trio provides triple protection in a single, monthly chew. It's available from your vet with a prescription and comes with a
100% satisfaction guarantee.
Simparica Trio vs. The Competition
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| Kills 6 Types of Ticks† |  |
| Prevents Lyme Infections* | |
| Kills Fleas Before They Can Lay Eggs†† | |
| Prevents Heartworm Disease | |
| Treats Roundworms‡‡ | |
| Treats Hookworms§§ | |
| Prevents Flea Tapeworm Infections## | |
| Treats Existing Tapeworm Infections** | |
| Approved for Dogs 8 Weeks+ | |
| Approved for Dogs 2.8lbs+ | |
| Can Be Given Without a Meal | |
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Heartgard® PLUS2 |
NexGard®*3 |
NexGard® PLUS4 |
Bravecto®5 |
Credelio Quattro™6 |
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Only 5 Types‡ |
Only 5 Types§ |
Only 5 Types# |
Only 4 Types** |
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Only 1 Type** |
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It's Time to Enhance Your Dog's Parasite Protection
Ready to make the switch? Get the ultimate protection for your pup and speak to your vet about getting a prescription.
Important Safety Information: Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information.
SIMPARICA TRIO is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections. SIMPARICA TRIO kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, and the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (Asian longhorned tick) for one month in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater. SIMPARICA TRIO is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.
References:
Kynetec PetTrack US FTH National Data January 10, 2025.
Heartgard® Plus, Boehringer Ingelheim Animal Health USA Inc.
NexGard®, Boehringer Ingelheim Animal Health USA Inc.
NexGard® Plus, Boehringer Ingelheim Animal Health USA Inc.
Bravecto®, Intervet Inc, a subsidiary of Merck and Company Inc
- Credelio Quattro™ Elanco U.S. Inc, Greenfield Indiana 46140
