The #1 Vet Prescribed Combo Preventative<sup>1</sup>
The #1 Vet Prescribed Combo Preventative1
The Only Combo Preventative to Kill 6 Types of Ticks<sup>2</sup>
The Only Combo Preventative to Kill 6 Types of Ticks2
The First Combo Preventative To Block Lyme Infections*
The First Combo Preventative To Block Lyme Infections*

Simparica Trio vs. The Competition

img-simparica-trio-compare-table-logo.svg
Kills 6 Types of Ticks dark green checkmark
Prevents Lyme Infections* dark green checkmark
Kills Fleas Before They Can Lay Eggs dark green checkmark
Prevents Heartworm Disease dark green checkmark
Treats Roundworms dark green checkmark
Treats Hookworms dark green checkmark
Prevents Tapeworms** dark green checkmark
Treats and Controls Tapeworms
Approved for Dogs 8 Weeks+ dark green checkmark
Approved for Dogs 2.8lbs+ dark green checkmark
Can Be Given Without a Meal dark green checkmark

*By killing deer ticks**Prevents flea tapeworm (Diplydium caninum) by killing fleas.

2Simparica Trio: Simparica Trio starts killing deer ticks within 8 hours and starts killing fleas within 4 hours. For the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections, and treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Haemaphysalis longicornis (Asian longhorned tick), Ixodes scapularis (black-legged tick), and Rhipicephalus sanguineus (brown dog tick). 3Heartgard® PLUS, Boehringer Ingelheim Animal Health USA Inc.: For the treatment and control of roundworms (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense). 4Nexgard®, Boehringer Ingelheim Animal Health USA Inc.:  For the treatment and control of Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), Amblyomma americanum (lone star tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (longhorned tick) infestations, and for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks. 5Nexgard® PLUS, Boehringer Ingelheim Animal Health USA Inc.: For the treatment and control of adult hookworm (Ancylostoma caninum, Ancylostoma braziliense, and Uncinaria stenocephala) and roundworm (Toxocara canis and Toxascaris leonina) infections, and the treatment and control of Haemaphysalis longicornis (Asian longhorned tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), Dermacentor variabilis (American dog tick), and Amblyomma americanum (lone star tick) infestations and for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks. 6Bravecto®, Intervet Inc, a subsidiary of Merck and Company Inc.: For the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (Asian longhorned tick)] for 12 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater, and for the treatment and control of Amblyomma americanum (lone star tick) infestations for 8 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater. Bravecto is not effective against Amblyomma americanum ticks beyond 8 weeks after dosing. 7Credelio Quattro™ Elanco U.S. Inc.: For the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina), hookworm (fourth stage larvae (L4), immature adult, and adult Ancylostoma caninum, adult Uncinaria stenocephala), and tapeworm (Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosus) infections, and the treatment and control of tick infestations [Amblyomma americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), and Rhipicephalus sanguineus (brown dog tick)].

It's Time to Enhance Your Dog's Parasite Protection

Ready to make the switch? Get the ultimate protection for your pup and speak to your vet about getting a prescription.

Find A VetLearn More

Important Safety Information: Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information.

SIMPARICA TRIO is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections. SIMPARICA TRIO kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, and the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (Asian longhorned tick) for one month in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater. SIMPARICA TRIO is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.

References:

  1. Kynetec PetTrack US FTH National Data January 10, 2025.

ZPC-01080R9

The product information provided in this site is intended only for residents of the United States. The products discussed herein may not have marketing authorization or may have different product labeling in different countries. The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient. 

All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. ©2025 Zoetis Services LLC. All rights reserved. ZPC-01562R2