Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets)
Prevents Lyme Infections*dark green checkmark
Prevents Heartworm Diseasedark green checkmark
Kills 5 Types of Ticksdark green checkmark
Kills Fleasdark green checkmark
Kills Fleas Before They Can Lay Eggsdark green checkmark
Treats Roundwormsdark green checkmark
Treats Hookwormsdark green checkmark

Approved for Dogs
8 Weeks+

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Approved for Dogs

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*As a direct result of killing deer ticks

Important Safety Information: Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. See Prescribing Information.


  1. Heartgard® Plus [package insert], Duluth, GA: Boehringer Ingelheim Group; 2019
  2. NexGard® [package insert], Duluth, GA: Boehringer Ingelheim Group; 2023.
  3. Bravecto® [package insert], Summit, NJ: Merck & Co; 2023.
  4. Credelio® [package insert], Greenfield, IN: Elanco; 2020.
  5. Interceptor® Plus [package insert]. Greenfield, IN: Elanco; 2021.

Heartgard and NexGard are registered trademarks of Boehringer Ingelheim Animal Health USA Inc. Bravecto is a registered trademark of Intervet Inc. d/b/a Merck Animal Health. Credelio, Interceptor, and Trifexis are registered trademarks of Elanco or its affiliates.