Because Every Cat Needs Parasite Protection

The most prescribed medicine for feline parasite protection.¹

Did you know itty bitty invaders can come indoors by grasping to your clothes or clinging to your shoes? Revolution Plus protects your cat inside and out against fleas, ticks, ear mites, roundworms, hookworms, and heartworm disease.

Why does your cat need Revolution Plus?

Pest Protection Both Indoor and Outdoor Cats Need

One application a month can help protect your cat from the most common parasites.
Revolution Plus is a simple-to-apply, quick-drying, small-volume, monthly topical solution.
Provides dual action against fleas by combining the power of selamectin and sarolaner.
Safe for cats and kittens as young as 8 weeks of age, weighing 2.8 lbs or more.

Protect Your Cat From Sneaky Pests

Parasites are not “outdoor-only.” Any cat or kitten can regularly come in contact with harmful pests. Parasites hitchhike indoors on other pets and creatures, on your shoes and clothes, or through doors and windows.

Fleas

Why should I care about fleas?

Fleas can hitchhike indoors on your cat, other pets or creatures, on shoes and clothes, or get inside through doors and windows.
Tapeworms and fleas tend to go hand in hand. That's because fleas can host tapeworms and then give them to your cat. So when you keep your cat protected from fleas, you help reduce their risk from tapeworms.²
Flea bites can cause intense itching and allergies. This scratching can lead to hair loss and uncomfortable skin irritations.²

In 2 clinical studies, one dose of Revolution Plus killed 100% of adult fleas for a full 5 weeks.³ In a separate study, Revolution Plus started killing fleas within 6 hours of re-infestations.³

Ticks

Why should I care about ticks?

Ticks can be found anywhere in the United States—any time of year in both rural and urban environments⁴
Ticks can spread several diseases in cats^4,5
They can cause skin irritation and allergic reactions^4,5

Revolution Plus kills 3 types of ticks for a full month after one dose, including black-legged ticks (a.k.a. deer ticks) American dog ticks and Gulf Coast ticks.^6,7 Effective results sustained for up to 5 weeks for black-legged or deer tick and American dog tick.^6,8

Ear mites

Why should I care about ear mites?

These “hitchhikers” can invade your home on other pets and cause severe irritation, including:⁹

Red, itchy, painful ears
Dark brown discharge in the ears
Inflamed ears that could lead to rash or other skin reactions
Damage to the ears caused by excessive scratching
Transmission to other cats and pets through direct contact

In a clinical study, Revolution Plus killed over 99% of ear mites for a full month after one dose.³

Roundworms

Why should I care about roundworms?

Roundworms get into your home—and into your cat—through contaminated soil, the dirt on your shoes, or infected prey like rodents or bugs^10,11
Major roundworm infections in cats can cause vomiting, weight loss, hair changes and a potbellied appearance^10,11

In a clinical study, Revolution Plus reduced nearly 100% of roundworm eggs after a single dose.¹²

Hookworms

Why should I care about hookworms?

Hookworms can cause anemia, weight loss, and diarrhea in infected cats¹³
Severe hookworm infections can be fatal, especially in kittens¹³

In a clinical study, Revolution Plus reduced over 99% of hookworm eggs after a single dose.¹²

Heartworms

Why should I care about heartworms?

At least 1 in 4 cats with heartworm disease were classified as indoor-only¹⁴
Heartworm disease in cats isn’t just serious—it can be fatal^14,15
Just 1 bite from an infected mosquito can give your cat heartworms¹⁵
Even when it isn’t deadly, heartworm infection in cats can cause permanent lung damage known as heartworm-associated respiratory disease (HARD)^15,16
Heartworm disease can be difficult to diagnose in cats, but is easy to prevent

In TWO clinical studies, Revolution Plus was 100% effective in preventing heartworm disease.³

Frequently Asked Questions

: How is Revolution Plus different from Revolution?
Revolution Plus is vets’ #1 trusted choice in feline parasite protection, building upon the proven legacy protection of Revolution to now protect against ticks, too.^1,3

With one monthly dose, Revolution Plus broadens the scope of pest protection to common parasites that are harmful for both indoor and outdoor cats and kittens, with unique dual action against fleas and ear mites.
: What parasites does Revolution Plus protect against?
Revolution Plus broadens the scope of protection for cats and kittens, inside and out, against fleas, ticks, ear mites, roundworms, hookworms, and heartworms.^4,5
: My cat only lives indoors. Is parasite protection necessary?
Parasites are not outdoor-only. Fleas, ticks, ear mites, intestinal worms, and mosquitos that transmit heartworms can get into any home. Parasites hitchhike indoors on other pets or creatures, on shoes and clothes, or get inside through doors and windows. Cats and kittens of all lifestyles (indoor-only, indoor/outdoor, outdoor-only) can regularly come in contact with parasites and their health risks. With one monthly dose, Revolution Plus provides broad-spectrum coverage against common pests that both indoor and outdoor cats need.
: Are ticks common in cats?
Though certain ticks are more prominent in certain areas (ie, Gulf Coast tick in southeastern and mid-Atlantic states; American dog tick east of the Rocky Mountains and Pacific coast; black-legged or deer tick across eastern US), cat parents should be vigilant with year-round tick and other pest protection in all 50 states to ensure cats of all lifestyles (indoor-only, indoor/outdoor, outdoor-only) are properly protected with broad-spectrum preventative medicine such as Revolution Plus.

Learn More
: How can I decide which pest protection is best for my cat?
It’s always best to talk with your veterinarian about the right protection for your furry friend. But a good start is looking at the comparison chart to see how the Revolution Plus label compares to those of other pest preventatives. Revolution Plus provides broad-spectrum, protection against fleas, ticks (black-legged or deer tick, Gulf Coast tick, and American dog tick), ear mites, roundworms, hookworms, and heartworm disease, with unique dual action against fleas and ear mites. Revolution Plus has a simple application that does not require gloves or separation of your cat from family or other pets.
: How do I apply Revolution Plus to my cat?
Revolution Plus is a simple-to-apply, quick-drying, small-volume, monthly topical solution—so there’s no need to hassle with larger volume topicals or giving your cat a pill! Check out our illustrated how-to guide.

There is no need to wear gloves to apply Revolution Plus, or to separate your cat from family or other pets after application.

Learn More
: What are the side effects of Revolution Plus for cats?
The most commonly reported side effects in clinical trials were temporary loss of appetite and drowsiness. No side effects were noted when Revolution Plus was used along with commonly prescribed veterinary products.

While there was a low incidence of side effects in clinical trials, it’s important to report to your veterinarian any unusual signs or activity in your cat or kitten after applying the product.
: Is Revolution Plus safe for cats and kittens?
Revolution Plus has been demonstrated safe for cats and kittens as young as 8 weeks of age, weighing 2.8 lbs or more. It is also labeled for use in cats regardless of heartworm status—unlike some other treatments. The safe use of Revolution Plus has not been established in kittens less than 8 weeks old or in breeding, pregnant, or lactating cats.

Because one of the active ingredients (sarolaner) in Revolution Plus is a member of the isoxazoline class, use with caution in cats with a history of neurologic disorders such as seizures. Revolution Plus has been administered in conjunction with numerous cat medications and can be safely used in heartworm-positive cats.
: Where is Revolution Plus manufactured?
Zoetis manufactures Revolution Plus in Kalamazoo, Michigan.
: Where can I get Revolution Plus?
Revolution Plus is a medication prescribed by your veterinarian and can be purchased either at your veterinarian or anywhere you can purchase prescription pet medications. Please contact your veterinarian to discuss Revolution Plus for your cat or kitten.

IMPORTANT SAFETY INFORMATION: See Prescribing Information. The safe use of Revolution Plus has not been established in kittens less than 8 weeks old or in breeding, pregnant or lactating cats. Reported side effects in clinical trials included lethargy and anorexia. Use with caution in cats with a history of neurologic disorders. Sarolaner, one of the ingredients in Revolution Plus, is a member of the isoxazoline class, which has been associated with adverse reactions such as tremors, ataxia, and seizures. Reactions have occurred in cats with or without a history of neurologic disorders. In humans, Revolution Plus may be irritating to skin and eyes.

Revolution Plus is a simple-to-apply, quick-drying, small-volume, monthly topical solution that protects against fleas (Ctenocephalides felis), ticks (black-legged or deer tick [Ixodes scapularis], Gulf Coast tick [Amblyomma maculatum] and American dog tick [Dermacentor variabilis]), ear mites (Otodectes cynotis), roundworms (Toxocara cati), hookworms (Ancylostoma tubaeforme), and heartworms (Dirofilaria immitis) for cats and kittens as young as 8 weeks of age and weighing 2.8 pounds or greater.

References:

Vetstreet FTH Projection February 2021. Canine and Feline Flea, Tick, Heartworm Market Share. February 2021. Data on file. Zoetis Inc.
Cat Owners – Fleas. Companion Animal Parasite Council. Available at: https://www.pets and parasites.org/cat-owners/fleas/. Access Spetember 2018.
Revolution Plus (selamectin and sarolaner topical solution) [package insert]. Zoetis Inc. Kalamazoo, MI. Novemebr 2018.
Cat Owners – Ticks. Companion animal Parasite Council. Available at: https://www.petsandparasites.org/cat-owners/ticks/. Accessed September 2018.
Stegmann MR, Sherington J, Blanchflower S. Pharmacokinetics and pharmacodynamics of cefovecin in dogs. J Vet Pharmacol Ther. 2006;29(6):501-511.
Zoetis Data on File, Study Report A186C-US-14-100, 2014.
Zoetis Data on File, Study Report A186C-US-14-106, 2014.
Zoetis Data on File, Study Report A186C-US-14-098, 2014.
Ticks—Cat. Companion Animal Parasite Council. Available at: https://www.capcvet.org/guidelines/ticks/. Accessed September 2018.
Gastrointestinal parasites of cats. Cornell University College of Veterinary Medicine. Available at: https://www.vet.cornell.edu/departments-centers-and-institutes/cornell feline-health-center/health-information/feline-health-topics/gastrointestinal-parasites-cats-brochure. Accessed June 2018.
Cat Owners – Roundworms. Companion Animal Parasite Council. Available at: https://www.petsandparasites.org/cat-owners/roundworms/. Accessed September 2018
Zoetis Data on File, Study Report A181C-US-15-166, 2017.
Cat Owners – Hookworms. Companion Animal Parasite Council. Available at: https://www.petsandparasites.org/cat-owners/hookworms/. Accessed September 2018.
Atkins CE, DeFrancesco TC, Coats JR, Sidley JA, Keene BW. Heartworm infection in cats: 50 cases (1985-1997). J Am Vet Med Assoc. 2000:217(3):355-358.
Cat Owners – Heartworms. Companion Animal Parasite Council. Available at: https://www.petsandparasites.org/cat-owners/heartworms/. Accessed September 2018.
Heartworm in cats. American Heartworm Society. Available at: https://www.heartwormssociety.org/heartworms-in-cats. Accessed June 2018.

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The product information provided in this site is intended only for residents of the United States. The products discussed herein may not have marketing authorization or may have different product labeling in different countries. The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient. Sileo® is trademark owned by Orion Corporation Orion Pharma Animal Health. It is manufactured by Orion Corporation and distributed by Zoetis under license from Orion Corporation Orion Pharma Animal Health.

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Protect Your Cat From Parasites That Follow You Home

Because Every Cat Needs Parasite Protection

Pest Protection Both Indoor and Outdoor Cats Need

Protect Your Cat From Sneaky Pests

Suggested Articles

Frequently Asked Questions