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Because NOTHING should come between you and your cat
REVOLUTION PLUS (selamectin and sarolaner topical solution)

6-in-1 pest protection for every cat, every lifestyle, every month

REVOLUTION PLUS provides the broadest scope of protection in one dose, protecting cats and kittens inside and out against flea, ticks, ear mite, roundworms, hookworms, and heartworms.

Building on the Trusted Legacy of REVOLUTION® (selamectin)

Veterinarian' #1 Choice for CatsNo separation from family needed—owners just wash their hands and continue cat care as usual.

See how REVOLUTION PLUS protects your cat

Cat looking to the side.
Box and one dose of Revolution Plus.

Protect your cat from 6 common parasites with one dose of REVOLUTION PLUS

REVOLUTION PLUS provides the broadest available feline parasite protection in one easy-to-use, monthly dose. No wonder it's veterinarians' #1 choice in feline parasite protection!1

Why your cat needs parasite protection

Parasites are NOT “outdoor-only.” Cats and kittens of every lifestyle can regularly come in contact with harmful pests. Parasites hitchhike indoors on other pets or creatures, on shoes and clothes, or get inside through doors and windows. 

REVOLUTION PLUS safely protects cats and kittens as young as 8 weeks of age from common parasites such as:

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Earn up to $35 in rewards while protecting your cat from fleas and other common pests

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    REVOLUTION PLUS provides the broadest pest protection for indoor and outdoor cats

    • One monthly dose protects indoors and outdoor cats against 6 common parasites
    • Safe for cats and kittens as young as 8 weeks of age, weighing 2.8 lbs or greater
    • Simple-to-apply, quick drying, small volume, monthly topical solution that does not requires gloves to apply - just wash hands and engage with your cat as usual

    Compare the labels of other products with REVOLUTION PLUS

    Pest Protection Revolution Plus (selamectin and sarolaner topical solution) Pest Protection Revolution Plus (selamectin and sarolaner topical solution)
    Adult fleas dark blue checkmark
    Ticks
    • 3 types
    • Black-legged/deer
    • American Dog
    • Gulf Coast
    Ear mites dark blue checkmark
    Roundworms/Hookworms dark blue checkmark
    Heartworms** dark blue checkmark
    Safety Revolution Plus (selamectin and sarolaner topical solution) Safety Revolution Plus (selamectin and sarolaner topical solution)
    Youngest age 8 weeks
    Lowest weight 2.8 lbs
    FDA or EPA approved FDA
    Separation requirements None
    Application requires gloves
    Use with caution in heartworm+ cats

    How to apply REVOLUTION PLUS

    REVOLUTION PLUS is a simple-to-apply, quick-drying, small-volume, monthly topical solution that protects cats and kittens from pests with convenient once-monthly dosing.

    The tube should be removed from the protective package immediately before application.

    As simple as 1-2-3:

    Steps 1, Step 2, Step 3

    1. Press cap until you hear a "click"
      Hold tube upright and press the cap to puncture the seal. Remove cap and make sure tip is open.
    2. Part neck hair and squeeze tube
      Part the fur at the base of your cat's neck and touch tube tip to visible skin. Squeeze tube 3 or 4 times in one spot.
    3. Glide tube, lift and discard
      Keeping the tube squeezed, glide it along the skin and away from the liquid, then lift off. Ensure the tube is empty before throwing it out.

    Avoid contact between the product and fingers. Do not massage REVOLUTION PLUS into the skin. Do not apply when the haircoat is wet. Do not apply to broken skin—REVOLUTION PLUS contains alcohol. Discard empty tubes in your ordinary household refuse. Prescribing Information

    Woman with her hand on cat, looking at her pet lovingly.

    Frequently Asked Questions

    IMPORTANT SAFETY INFORMATION: The safe use of Revolution Plus has not been established in kittens less than 8 weeks old or in breeding, pregnant or lactating cats. Reported side effects in clinical trials included lethargy and anorexia. Use with caution in cats with a history of neurologic disorders. Sarolaner, one of the ingredients in Revolution Plus, is a member of the isoxazoline class, which has been associated with adverse reactions such as tremors, ataxia, and seizures. Reactions have occurred in cats with or without a history of neurologic disorders. In humans, Revolution Plus may be irritating to skin and eyes. See full Prescribing Information

    Revolution Plus is a simple-to-apply, quick-drying, small-volume, monthly topical solution that protects against fleas (Ctenocephalides felis), ticks (black-legged or deer tick [Ixodes scapularis], Gulf Coast tick [Amblyomma maculatum] and American dog tick [Dermacentor variabilis]), ear mites (Otodectes cynotis), roundworms (Toxocara cati), hookworms (Ancylostoma tubaeforme), and heartworms (Dirofilaria immitis) for cats and kittens as young as eight weeks of age and weighing 2.8 pounds or greater.

    References:
    1. Vetstreet FTH Projection February 2020. Canine and Feline Flea, Tick, Heartworm Market Share. February 2020. Data on file. Zoetis Inc.
    2. Indoor Cats Parasiticides Tracker: “Stock Up” survey; fielded on 5/21-6/5/2018. Data on file. Zoetis Inc.
    3. Cat Owners — Fleas. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/fleas/. Accessed September 2018.
    4. Fleas — Cat. Companion Animal Parasite Council. Available at: https://www.capcvet.org/guidelines/fleas/. Accessed September 2018.
    5. Foil CS. Flea Allergy. Annual Dermatology Conference, Louisiana State University, December 11, 2005. Available at: http://www.lsu.edu/vetmed/veterinary_hospital/services/dermatology/ce_lectures/flea_ allergy.php. Accessed June 2018.
    6. Zoetis Data on file, Study Report A186C-US-14-100, 2014.
    7. Zoetis Data on file, Study Report A186C-US-14-106, 2014.
    8. Zoetis Data on File, Study Report: A186C-US-14-098, 2014.
    9. Cat Owners — Ticks. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/ticks/. Accessed September 2018.
    10. Geographic distribution of ticks that bite humans. Available at: https://www.cdc.gov/ticks/geographic_distribution.html. Accessed September 2018.
    11. Ticks — Cat. Companion Animal Parasite Council. Available at: https://www.capcvet.org/guidelines/ticks/. Accessed September 2018.
    12. Cat Owners — Ear Mites. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/ear-mites. Accessed September 2018.
    13. Zoetis Data on file, Study Report A181C-US-15-166, 2017.
    14. Gastrointestinal parasites of cats. Cornell University College of Veterinary Medicine. Available at: https://www.vet.cornell.edu/departments-centers-and-institutes/cornell-feline-health-center/health-information/feline-health-topics/gastrointestinal-parasites-cats-brochure. Accessed June 2018.
    15. Cat Owners — Roundworms. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/roundworms/. Accessed September 2018.
    16. Cat Owners — Hookworms. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/hookworms/. Accessed September 2018.
    17. Atkins CE, DeFrancesco TC, Coats JR, Sidley JA, Keene BW. Heartworm infection in cats: 50 cases (1985-1997). J Am Vet Med Assoc. 2000;217(3):355-358.
    18. Cat Owners — Heartworms. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/heartworms/. Accessed September 2018.
    19. Heartworm in cats. American Heartworm Society. Available at https://www.heartwormsociety.org/heartworms-in-cats. Accessed June 2018.
    20. REVOLUTION® [package insert]. Kalamazoo, MI: Zoetis Inc; 2018.
    21. Advantage Multi [package insert]. Shawnee Mission, KS: Bayer Animal Health; 2016.
    22. Frontline Gold brochure. Your golden opportunity awaits; 2017. Merial, Inc. Duluth, GA; 2017.
    23. Bravecto Topical Solution for Dogs [prescribing information]. Madison, NJ. Merck Animal Health; 2016.

    Advantage Multi is a registered trademark of Bayer. Bravecto is a registered trademark of Merck Animal Health. Frontline Gold is a registered trademark of Merial.

    RVP-00291

    The product information provided in this site is intended only for residents of the United States. The products discussed herein may not have marketing authorization or may have different product labeling in different countries. The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient. Sileo® is trademark owned by Orion Corporation Orion Pharma Animal Health. It is manufactured by Orion Corporation and distributed by Zoetis under license from Orion Corporation Orion Pharma Animal Health.

    All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. ©2021 Zoetis Services LLC. All rights reserved. ZPC-00097R1