The 5 Best Flea Treatments for Cats in 2025

A cat walking across a lush green field.

All cats should receive flea prevention to help protect them from discomfort and serious health issues. Fleas can also infest homes, affecting humans and other pets. Regular flea prevention ensures a healthier, happier cat and a cleaner living environment. Business Insider recently reviewed the best flea and tick treatments for cats in 2025, and chose Revolution® Plus (selamectin and sarolaner topical solution) as the overall pick for a prescription topical flea and tick treatment for cats.

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IMPORTANT SAFETY INFORMATION: The safe use of Revolution Plus has not been established in kittens less than 8 weeks old or in breeding, pregnant or lactating cats. Reported side effects in clinical trials included lethargy and anorexia. Use with caution in cats with a history of neurologic disorders. Revolution Plus contains sarolaner, a member of the isoxazoline class which has been associated with neurologic adverse reactions, such as tremors, ataxia, and seizures in cats with or without a history of neurologic disorders. In humans, Revolution Plus may be irritating to skin and eyes. See Prescribing Information.

REVOLUTION PLUS is indicated for the prevention of heartworm disease caused by Dirofilaria immitis, the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections, and the treatment and control of ear mite (Otodectes cynotis) infestations. REVOLUTION PLUS kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, the prevention of Dipylidium caninum (tapeworm) infections as a direct result of killing Ctenocephalides felis vector fleas on the treated cat, and the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), and Ixodes scapularis (black-legged tick) for one month in cats and kittens 8 weeks and older, and weighing 2.8 pounds or greater.