Ask your veterinarian about the benefits of adding ProHeart 12 to your annual wellness visit.
With no monthly doses to remember, there are no gaps in protection for a full year. It’s so important to keep your dog protected. Just one missed dose of any heartworm preventative can result in heartworm disease, a potentially fatal condition.
Just one dose of ProHeart 12 provides protection for your dog all year long.
ProHeart 6 is a twice-yearly dose to prevent heartworm disease in dogs
20 million doses sold over a 10‑year period3
Demonstrated safe in special populations like:4
Dogs sensitive to ivermectin—a common ingredient in monthly products for heartworm disease
Many common medicines were given at the same time in clinical trials
Please see full Prescribing Information for ProHeart 6.
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IMPORTANT SAFETY INFORMATION: Use PROHEART 6 in dogs 6 months of age or older and PROHEART 12 in dogs 12 months of age or older. Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. Hypersensitivity reactions may occur in some dogs when PROHEART is administered alone or with vaccines. Anaphylactic and anaphylactoid reactions can result in death and should be treated immediately with the same measures used to treat hypersensitivity reactions to vaccines and other injectable products. Reported side effects in clinical trials included vomiting, lethargy, diarrhea, anorexia, and hypersensitivity reactions. People should avoid inhalation, contact with eyes, or accidental self-injection. Certification is required before veterinarians and staff administer these products. See full Prescribing Information for ProHeart 6 and ProHeart 12.
*From an infected mosquito. †Caused by Dirofilaria immitis.
AHS Canine Guidelines 2020. https://d3ft8sckhnqim2.cloudfront.net/images/pdf/2020_AHS_Canine_Guidelines.pdf?1580934824, accessed 1/27/21.
McTier, T.L., Kryda, K., Wachowski, M. et al. ProHeart® 12, a moxidectin extended-release injectable formulation for prevention of heartworm (Dirofilaria immitis) disease in dogs in the USA for 12 months. Parasites Vectors 12, 369 (2019).
ProHeart 6 Pharmacovigilance Data. Data on file. Zoetis. Inc.
ProHeart 6 Freedom of Information Summary: 2001/06/06 Original NADA 141-189
ProHeart 12 Pharmacovigilance Data. Data on File. Zoetis Inc.
European Commission 2006. Volume 6C Summary of the Product Characteristics: SPC – Pharmaceuticals. https://ec.europa.eu/health/sites/health/files/files/eudralex/vol-6/c/spcpharmaceuticals_10-07-2006_en.pdf, accessed 2/1/21.