Coronavirus and Your Pets: Information for Pet Parents. Learn More

ONE BITE* can give a dog heartworm disease.^† ONE ProHeart 12 injection ensures ONE FULL YEAR of constant protection.

ProHeart 12 is the only once-yearly injection to prevent heartworm disease^† in dogs

A convenient once-a-year injection—so you don’t have to worry about forgetting a monthly dose and leaving your best friend exposed to heartworm disease.

*From an infected mosquito. ^†Caused by Dirofilaria immitis.

See why it only takes ONE with ProHeart 12

“It Only Takes One” Video

ProHeart 12 is here year-round to protect your dog

ProHeart 12 fits in with annual wellness visits

With no monthly doses to remember, there are no gaps in protection for a full year. It’s so important to keep your dog protected. Just one missed dose of any heartworm preventative can result in heartworm disease, a potentially fatal condition.

Just one shot of ProHeart 12 provides protection for your dog all year long.

Learn More

Ask your veterinarian about the benefits of ProHeart 12

It only takes one

ProHeart 12 makes it simple to protect your dog from heartworm disease.

Heartworm disease is preventable—but are monthly chewables right for you and your dog?

There are other options to prevent heartworm disease, but before you commit to monthly chewables, consider this:

When life gets busy, it can be tough to stay on top of monthly dosing—and many pet owners do forget¹
Dogs may vomit or spit out the chews, which means the pet owner has to redose
Some dogs refuse to eat “treat-like” preventatives

Monthly chewables offer 12 chances to miss a dose!

See what pet owners and veterinarians are saying about ProHeart 12

View Testimonials

One dose: constant protection for your dog means constant peace of mind for you

Heartworm disease can be deadly. ProHeart 12 is a long-lasting injectable that prevents heartworm disease for 12 months, plus:

You can easily fit in heartworm disease prevention with ProHeart 12 when you go for your dog’s yearly vet visit
The convenience of a once-a-year injection means you don’t have to worry about forgetting a monthly dose and putting your dog at risk for heartworm disease

ProHeart 12 is effective & safe

In a real-world study, ProHeart 12:

Was 100% effective against heartworm* in dogs^†
Was found to be safe for most types of dogs, including:

Reproducing dogs and their puppies
Collies sensitive to ivermectin—a common ingredient in monthly heartworm products

Had a similar adverse event profile to Heartgard® Plus

*Caused by Dirofilaria immitis. ^†In 3 well-controlled studies.
Heartgard Plus is a registered trademark of Boehringer Ingelheim.

What Pet Owners and Doctors are saying about ProHeart 12

Year-round protection has a lot of benefits. Hear what pet owners have to say about what ProHeart does for their dogs, their families and their peace of mind.

Zoetis has sold more than 12 million doses* of ProHeart 12^† over a 10‑year period with a rare rate of adverse events^‡2

*Doses sold are calculated using standard dog weight of 44 lbs and provide an estimate of the number of dogs treated. The actual number of dogs treated can’t be determined from sales or adverse drug events data.^†Known outside the US as ProHeart SR-12. ^‡Rare means more than 1 but less than 10 animals in 10,000.³ This is a reporting rate, because the total number of dogs treated is unknown. Reporting rates can underestimate the actual number of adverse events, due to under-reporting of adverse events.

How do dogs get infected with heartworms?

The short answer: mosquitoes. A single bite from an infected mosquito can put your dog at risk for developing heartworm disease.

An infected mosquito bites your dog, infecting your dog with heartworm larvae.
The heartworms then mature inside your dog, living in major vessels around the heart and even sometimes inside the heart itself.
It could take longer than 7 months for the heartworms to be detectable with routine testing. An adult heartworm can grow up to a foot in length, living inside your dog’s heart and lungs.⁴

Any dog, even your dog, could become infected

Heartworm disease has been diagnosed in every state and is a serious threat to your dog.

Early disease and damage can happen even before a test can detect heartworms⁵
Heartworm disease has increased over 21% during a 3-year period and is expected to continue to spread*^6,7
Treating heartworm is up to 25^† times more expensive than simply preventing it⁸

Once a dog is diagnosed with heartworm disease, a pet owner may have to pay for doctor’s visits, medications, post-treatment preventatives, lab tests, x-rays, and other medical expenses

*Per veterinary clinic, 2013-2016. ^†Calculation is based on American Heartworm Society cost estimations of treatment vs prevention (where heartworm prevention range is $70-$200, and heartworm treatment range is $1,200-$1,800; [low range] $1,200/$70=17.14, [high range] $1,800/$200=9, [High/Low comparison] $1,800/$70=25.71).

ProHeart 6® (moxidectin): another reliable option

ProHeart 6 is a twice-yearly injection to prevent heartworm disease in dogs

20 million doses sold over a 10‑year period⁹
Safe in special populations like:

Reproducing dogs and their puppies
Dogs sensitive to ivermectin—a common ingredient in monthly heartworm products

Many common medicines were given at the same time in clinical trials

Please see full Prescribing Information for ProHeart 6.

Zoetis Petcare Rewards program for ProHeart purchases

Earn rewards while protecting your dog from heartworm disease

Join Now See Offers

: What is ProHeart 12?
ProHeart 12 is the only FDA-approved product that prevents heartworm disease in dogs for 1 full year with just 1 shot given by your veterinarian. At the time of the shot, ProHeart 12 also treats hookworms.* ProHeart 12 is for use in healthy dogs 12 months of age and older.

*ProHeart 12 is indicated for the treatment of existing larval and adult hookworm (Ancylostoma caninum and Uncinaria stenocephala) infections.
: How much does ProHeart 12 typically cost?
On average, the price of a ProHeart 12 shot is about the same as 12 months’ worth of a monthly heartworm disease preventative. Cost may vary depending on how much your dog weighs. Ask your veterinarian for details.
: Is ProHeart 12 right for my dog?
ProHeart 12 can be used in healthy dogs 12 months of age and older. Talk with your veterinarian about ProHeart 12 for your dog.
: Is ProHeart 12 safe?
Yes. In fact, in a clinical study with client-owned dogs, ProHeart 12 had a similar adverse event profile to Heartgard Plus. The most common side effects were vomiting, diarrhea, and lethargy.
: How does ProHeart 12 work?
ProHeart 12 provides 1 full year of heartworm disease prevention in just 1 shot. The active ingredient, moxidectin, is contained in slow-dissolving microspheres that are stored in your dog’s fat-storing connective tissue (a.k.a. adipose tissue). The medicine is then released evenly over 1 year’s time, keeping your buddy consistently protected from heartworms. Cool, right?
: What is heartworm disease?
Heartworm disease is serious and potentially fatal—and a single bite from an infected mosquito can cause it in your dog. See the basics about heartworm disease, including your dog’s risk and some of the signs and symptoms.
: Is ProHeart 12 a vaccine?
No, ProHeart 12 is not a vaccine because it does not stimulate the production of antibodies. ProHeart 12 is an injection of preventative medicine that slowly releases over time in your dog’s body.
: What’s the difference between ProHeart 6 and ProHeart 12?
ProHeart 6 provides 6 months of heartworm disease prevention for dogs and ProHeart 12 provides 1 full year of heartworm disease prevention for dogs. Dogs older than 6 months but less than 1 year old should be given ProHeart 6.
: Does my dog need a heartworm test before starting ProHeart 12?
It’s important to know if your dog has heartworms before starting a new heartworm product or switching to a different one. Not sure when your dog last had a heartworm test? Check with your veterinarian before giving any heartworm medication—not just when starting a new product or switching.
: What if my dog tests positive for heartworms before taking ProHeart 12?
Of course we all hope that won’t happen! But if it does, your veterinarian will want to start by running a different test to confirm the diagnosis. If that test also shows a positive result, your veterinarian will talk with you about a treatment plan.
: How do I switch from another heartworm disease preventative to ProHeart 12?
Talk with your veterinarian about switching to ProHeart 12 from another heartworm disease preventative.

Important Safety Information: Use PROHEART 6 in dogs 6 months of age or older and PROHEART 12 in dogs 12 months of age or older. Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. Hypersensitivity reactions may occur in some dogs when PROHEART is administered alone or with vaccines. Anaphylactic and anaphylactoid reactions can result in death and should be treated immediately with the same measures used to treat hypersensitivity reactions to vaccines and other injectable products. Reported side effects in clinical trials included vomiting, lethargy, diarrhea, anorexia, and hypersensitivity reactions. People should avoid inhalation, contact with eyes, or accidental self-injection. Certification is required before veterinarians and staff administer these products. See full Prescribing Information for ProHeart 6 and ProHeart 12.

References:

Make Heartworm Preventative Reminders a Priority. https://d3ft8sckhnqim2.cloudfront.net/images/bulletin/AHS-1606-Jun-16-Summer-Bulletin.pdf?1535051994.
ProHeart 12 Pharmacovigilance Data. Data on file. Zoetis Inc.
Volume 6C: Summary of the Product Characteristics: SPC - Pharmaceuticals 2006. Data on file. Zoetis Inc.
AHS Canine Guidelines 2018. https://d3ft8sckhnqim2.cloudfront.net/images/pdf/2018-AHS-Canine-Guidelines-181114.pdf?1542248135.
Jones S. Heartworm disease: What lies beneath; DVM 360. April 19, 2018.
Drake J, Wiseman S. Increasing incidence of Dirofilaria immitis in dogs in USA with focus on the southeast region 2013-2016. Parasit Vectors. (2018)11:39.
AHS announces findings of New Heartworm Incidence Survey. April 17, 2017. https://www.heartwormsociety.org/newsroom/in-the-news/347-ahs-announces-findings-of-new-heartworm-incidence-survey.
Weigh the costs: Heartworm treatment vs Heartworm prevention. https://d3ft8sckhnqim2.cloudfront.net/images/infographics/0010-weigh-the-costs.jpg.
ProHeart 6 Pharmacovigilance Data. Data on file. Zoetis Inc.

The product information provided in this site is intended only for residents of the United States. The products discussed herein may not have marketing authorization or may have different product labeling in different countries. The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient.

ZPC-00097

#react-view{ margin-top: 2rem; } .nojs-message{ position: absolute; z-index: 10; top: 0; width: 100%; text-align: center; padding: 1rem; background: #d60000; color: white; font-weight: 700; font-size: 18px; } This site requires JavaScript. Your browser has JavaScript disabled, please turn it on in your browser settings.