The tube should be removed from the protective package immediately before application.

As simple as 1-2-3:

Illustrated step 2 of applying Revolution Plus.
  1. Press cap until you hear a “click”.
    Hold tube upright and press the cap to puncture the seal. Remove cap and make sure tip is open.
  2. Part neck hair and squeeze tube.
    Part the fur at the base of your cat’s neck and touch tube tip to visible skin. Squeeze tube 3 or 4 times in one spot.
  3. Glide tube, lift and discard.
    Keeping the tube squeezed, glide it along the skin and away from the liquid, then lift off. Ensure the tube is empty before throwing it out.

Avoid contact between the product and fingers. Do not massage Revolution Plus into the skin. Do not apply when the haircoat is wet. Do not apply to broken skin—Revolution Plus contains alcohol. Discard empty tubes in your ordinary household refuse. Prescribing Information

Important Safety Information: The safe use of Revolution Plus has not been established in kittens less than 8 weeks old or in breeding, pregnant or lactating cats. Reported side effects in clinical trials included lethargy and anorexia. Use with caution in cats with a history of neurologic disorders. Revolution Plus contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions, such as termors, ataxia, and seizures in cats with or without a history of neurologic disorders. In humans, Revolution Plus may be irritating to skin and eyes.

Revolution Plus is a simple-to-apply, quick-drying, small-volume, monthly topical solution that protects against fleas (Ctenocephalides felis), ticks (lone star tick [Amblyomma americanum], black-legged or deer tick [Ixodes scapularis], Gulf Coast tick [Amblyomma maculatum] and American dog tick [Dermacentor variabilis]), ear mites (Otodectes cynotis), roundworms (Toxocara cati), hookworms (Ancylostoma tubaeforme), and heartworms (Dirofilaria immitis) for cats and kittens as young as 8 weeks of age and weighing 2.8 pounds or greater. See Prescribing Information.


  1. VS NexGard Combo and Bravecto Plus. Data on file.