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Girl and cat sleeping on bed, holding each other tight.
Because NOTHING should come between you and your cat
REVOLUTION PLUS (selamectin and sarolaner topical solution)
Veterinary Professionals

6-in-1 pest protection for every cat, every lifestyle, every month

REVOLUTION PLUS provides the broadest scope of protection in one dose, protecting cats and kittens inside and out against flea, ticks, ear mite, roundworms, hookworms, and heartworms.

Building on the Trusted Legacy of REVOLUTION® (selamectin)

Veterinarian' #1 Choice for CatsNo separation from family needed—owners just wash their hands and continue cat care as usual.

See how REVOLUTION PLUS protects your cat

Cat looking to the side.
Box and one dose of Revolution Plus.

Protect your cat from 6 common parasites with one dose of REVOLUTION PLUS

REVOLUTION PLUS provides the broadest available feline parasite protection in one easy-to-use, monthly dose. No wonder it's veterinarians' #1 choice in feline parasite protection!1

Why your cat needs parasite protection

Parasites are NOT “outdoor-only.” Cats and kittens of every lifestyle can regularly come in contact with harmful pests. Parasites hitchhike indoors on other pets or creatures, on shoes and clothes, or get inside through doors and windows. 

REVOLUTION PLUS safely protects cats and kittens as young as 8 weeks of age from common parasites such as:

Zoetis Petcare Rewards program for Revolution Plus purchases

Earn up to $35 in rewards while protecting your cat from fleas and other common pests

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Cat chasing fly, next to KitNipBox.

REVOLUTION PLUS provides the broadest pest protection for indoor and outdoor cats

  • One monthly dose protects indoors and outdoor cats against 6 common parasites
  • Safe for cats and kittens as young as 8 weeks of age, weighing 2.8 lbs or greater
  • Simple-to-apply, quick drying, small volume, monthly topical solution that does not requires gloves to apply - just wash hands and engage with your cat as usual

Compare the labels of other products with REVOLUTION PLUS

Pest Protection Revolution Plus (selamectin and sarolaner topical solution) Pest Protection Revolution Plus (selamectin and sarolaner topical solution)
Adult fleas dark blue checkmark
Ticks
  • 3 types
  • Black-legged/deer
  • American Dog
  • Gulf Coast
Ear mites dark blue checkmark
Roundworms/Hookworms dark blue checkmark
Heartworms** dark blue checkmark
Safety Revolution Plus (selamectin and sarolaner topical solution) Safety Revolution Plus (selamectin and sarolaner topical solution)
Youngest age 8 weeks
Lowest weight 2.8 lbs
FDA or EPA approved FDA
Separation requirements None
Application requires gloves
Use with caution in heartworm+ cats

How to apply REVOLUTION PLUS

REVOLUTION PLUS is a simple-to-apply, quick-drying, small-volume, monthly topical solution that protects cats and kittens from pests with convenient once-monthly dosing.

The tube should be removed from the protective package immediately before application.

As simple as 1-2-3:

Steps 1, Step 2, Step 3

  1. Press cap until you hear a "click"
    Hold tube upright and press the cap to puncture the seal. Remove cap and make sure tip is open.
  2. Part neck hair and squeeze tube
    Part the fur at the base of your cat's neck and touch tube tip to visible skin. Squeeze tube 3 or 4 times in one spot.
  3. Glide tube, lift and discard
    Keeping the tube squeezed, glide it along the skin and away from the liquid, then lift off. Ensure the tube is empty before throwing it out.

Avoid contact between the product and fingers. Do not massage REVOLUTION PLUS into the skin. Do not apply when the haircoat is wet. Do not apply to broken skin—REVOLUTION PLUS contains alcohol. Discard empty tubes in your ordinary household refuse. Prescribing Information

Woman with her hand on cat, looking at her pet lovingly.

Frequently Asked Questions

IMPORTANT SAFETY INFORMATION: The safe use of REVOLUTION PLUS has not been established in kittens less than 8 weeks old or in breeding, pregnant or lactating cats. Reported side effects in clinical trials included lethargy and anorexia. Use with caution in cats with a history of neurologic disorders. Sarolaner, one of the ingredients in REVOLUTION PLUS, is a member of the isoxazoline class, which has been associated with adverse reactions such as tremors, ataxia, and seizures. Reactions have occurred in cats with or without a history of neurologic disorders. In humans, REVOLUTION PLUS may be irritating to skin and eyes. See full Prescribing Information

REVOLUTION PLUS is a simple-to-apply, quick-drying, small-volume, monthly topical solution that protects against fleas (Ctenocephalides felis), ticks (black-legged or deer tick [Ixodes scapularis], Gulf Coast tick [Amblyomma maculatum] and American dog tick [Dermacentor variabilis]), ear mites (Otodectes cynotis), roundworms (Toxocara cati), hookworms (Ancylostoma tubaeforme), and heartworms (Dirofilaria immitis) for cats and kittens as young as eight weeks of age and weighing 2.8 pounds or greater.


References:
  1. Vetstreet FTH Projection February 2020. Canine and Feline Flea, Tick, Heartworm Market Share. February 2020. Data on file. Zoetis Inc.
  2. Indoor Cats Parasiticides Tracker: “Stock Up” survey; fielded on 5/21-6/5/2018. Data on file. Zoetis Inc.
  3. Cat Owners — Fleas. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/fleas/. Accessed September 2018.
  4. Fleas — Cat. Companion Animal Parasite Council. Available at: https://www.capcvet.org/guidelines/fleas/. Accessed September 2018.
  5. Foil CS. Flea Allergy. Annual Dermatology Conference, Louisiana State University, December 11, 2005. Available at: http://www.lsu.edu/vetmed/veterinary_hospital/services/dermatology/ce_lectures/flea_ allergy.php. Accessed June 2018.
  6. Zoetis Data on file, Study Report A186C-US-14-100, 2014.
  7. Zoetis Data on file, Study Report A186C-US-14-106, 2014.
  8. Zoetis Data on File, Study Report: A186C-US-14-098, 2014.
  9. Cat Owners — Ticks. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/ticks/. Accessed September 2018.
  10. Geographic distribution of ticks that bite humans. Available at: https://www.cdc.gov/ticks/geographic_distribution.html. Accessed September 2018.
  11. Ticks — Cat. Companion Animal Parasite Council. Available at: https://www.capcvet.org/guidelines/ticks/. Accessed September 2018.
  12. Cat Owners — Ear Mites. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/ear-mites. Accessed September 2018.
  13. Zoetis Data on file, Study Report A181C-US-15-166, 2017.
  14. Gastrointestinal parasites of cats. Cornell University College of Veterinary Medicine. Available at: https://www.vet.cornell.edu/departments-centers-and-institutes/cornell-feline-health-center/health-information/feline-health-topics/gastrointestinal-parasites-cats-brochure. Accessed June 2018.
  15. Cat Owners — Roundworms. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/roundworms/. Accessed September 2018.
  16. Cat Owners — Hookworms. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/hookworms/. Accessed September 2018.
  17. Atkins CE, DeFrancesco TC, Coats JR, Sidley JA, Keene BW. Heartworm infection in cats: 50 cases (1985-1997). J Am Vet Med Assoc. 2000;217(3):355-358.
  18. Cat Owners — Heartworms. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/heartworms/. Accessed September 2018.
  19. Heartworm in cats. American Heartworm Society. Available at https://www.heartwormsociety.org/heartworms-in-cats. Accessed June 2018.
  20. REVOLUTION® [package insert]. Kalamazoo, MI: Zoetis Inc; 2018.
  21. Advantage Multi [package insert]. Shawnee Mission, KS: Bayer Animal Health; 2016.
  22. Frontline Gold brochure. Your golden opportunity awaits; 2017. Merial, Inc. Duluth, GA; 2017.
  23. Bravecto Topical Solution for Dogs [prescribing information]. Madison, NJ. Merck Animal Health; 2016.

Advantage Multi is a registered trademark of Bayer. Bravecto is a registered trademark of Merck Animal Health. Frontline Gold is a registered trademark of Merial.

RVP-00291